Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) ELISA
BioMarkers | Diabetic Nephropathy | Fibrosis
Description
The K-ASSAY®Human Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) ELISA is an enzyme-linked immunosorbent assay for the quantitative determination of TIMP1 in human cell culture supernatant, serum, plasma and saliva.
TIMP-1, also known as erythroid-potentiating activity (EPA), is a 22- kDa glycoprotein that regulates connective tissue turnover by inhibiting the activity of matrix metalloproteinases (MMPs) such as MMP-2 and disintegrin-metalloproteinases. It also plays a role in cell differentiation, migration and apoptosis.
Imbalance of TIMPs is associated with tissue remodeling in atherosclerosis, fibrosis and inflammatory bowel disease (IBD) as well as degenerative diseases such as rheumatoid arthritis.
Specifications
Species reactivity | Human |
Sample type | Cell culture supernatant, serum, plasma, urine |
Assay type | Sandwich (quantitative) |
Range | 15.6–1,000 pg/mL |
Detection method | Colormetric |
Assay time | 3h 30min |
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Check also our broad collection of ANIMAL TIMP-1 ELISA Kits
Partner: Kamiya BioMedical Company
TIMP-1 ELISA - Product Insert | "Research Use Only"
Diabetic Nephropathy - BioMarker Overview
Download the BioMarker Overview Table here, including detailed information about 28 suggested biomarker assays.
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