Monocyte Chemotactic Protein-1 (MCP-1) ELISA
BioMarkers | Diabetic Nephropathy | Inflammation
Description
The K-ASSAY®Human Monocyte Chemoattractant Protein-1 (MCP-1) ELISA is an enzyme-linked immunosorbent assay for the quantitative determination of MCP-1 in human cell culture supernatant, serum, plasma and amniotic fluid.
MCP-1, also known as CCL2 and monocyte chemotactic and activating factor (MCAF), is one of the most thoroughly studied CC chemokines. It plays a central role in the recruitment of monocytes, T lymphocytes and NK cells to sites of injury/inflammation. In the vasculature, MCP-1 released by endothelial and smooth muscle cells binds to its complementary receptor (CCR2) on monocytes leading to their infiltration and activation in the subluminal space.
Elevated levels of MCP-1 is seen in diseases with a strong inflammatory component, such as atherosclerosis, nephropathy, rheumatoid arthritis, multiple sclerosis, and nonalcoholic steatohepatitis (NASH).
Specifications
Species reactivity | Human |
Sample type | Cell culture supernatant, serum, plasma, amniotic fluid |
Assay type | Sandwich (quantitative) |
Range | 74–760 pg/mL |
Detection method | Colormetric |
Assay time | 2h 30min |
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Check also our collection of ANIMAL MCP-1 ELISA Kits
Partner: Kamiya BioMedical Company
MCP-1 ELISA - Product Insert | "Research Use Only"
Diabetic Nephropathy - BioMarker Overview
Download the BioMarker Overview Table here, including detailed information about 28 suggested biomarker assays.
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