Tumor Necrosis Factor Alpha (TNFα) ELISA
The K-ASSAY®Human Tumor Necrosis Factor alpha (TNFα) ELISA is an enzyme-linked immunosorbent assay for the quantitative determination of TNFα in human cell culture supernatant, serum and plasma.
TNFα is a central regulator of inflammation and represents one of the cytokines of the acute phase response in the liver. It is produced by a variety of cell types, such as macrophages, lymphocytes and endothelial cells. Large amounts of TNF are released following exposure to bacterial products (for example lipopolysaccharide) as well as interleukins (IL)-1 and -6.
Upregulation of TNFα is observed in several inflammatory diseases including: inflammatory bowel disease (IBD), psoriasis, rheumatoid arthritis, diabetic nephropathy and cardiovascular diseases. Purified TNFα has shown cytotoxic and cytostatic activities against various human tumor cell lines.
Cell culture supernatant, serum, plasma
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TNFα ELISA - Product Insert | "Research Use Only"
Diabetic Nephropathy - BioMarker Overview
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