N-Acetyl-beta-Glucosaminidase (NAG) ELISA
BioMarkers | Diabetic Nephropathy | Injury and Dysfunction
Description
The K-ASSAY®Human N-acetyl-β D glucosaminidase (NAG) is a quantitative assay of human NAG in serum, plasma, cell culture supernatant body fluid and tissue homogenate.
NAG is a high molecular weight (140 kDa) lysosomal enzyme. It shows high activity in renal proximal tubule cells. Following tubular injury, NAG leaks into the tubular fluid and is detected in the urine. In some studies, urinary NAG : Creatinine is used as a surrogate marker of renal function.
Abnormally high levels of NAG are detected in kidney diseases including diabetic nephropathy, glomerulonephritis, tubulointerstitial diseases, renal allograft rejection, and toxic renal injury.
Specifications
Species reactivity | Human |
Sample type | Serum, plasma, cell culture supernatant body fluid and tissue homogenate |
Assay type | Competitive (quantitative) |
Sensitivity | 0.1 ng/mL |
Detection method | Colormetric |
Assay time | 1h 30min |
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Check also our collection of ANIMAL NAG ELISA Kits
Partner: Kamiya BioMedical Company
NAG ELISA - Product Insert | "Research Use Only"
Diabetic Nephropathy - BioMarker Overview
Download the BioMarker Overview Table here, including detailed information about 28 suggested biomarker assays.
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